Fri Jan 30 2026

68 articles - From Friday Jan 23 2026 to Friday Jan 30 2026

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastroenterology
AGA Clinical Practice Update on Inpatient Management of Adults With Inflammatory Bowel Disease: Expert Review.

BEST PRACTICE ADVICE 12: Hospitalized adult patients with Crohn's disease and active perianal symptoms should have a multidisciplinary treatment approach involving both medical and surgical care. BEST PRACTICE ADVICE 13: Stability of treatment response should be achieved before discharge, and a clear discharge transition plan established.

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Comparing Harms and Benefits of Pancreatic Cyst Surveillance Guidelines: A Microsimulation Study.

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Meta-analysis

meta-analyses and systematic reviews

Clin Gastroenterol Hepatol
Phenotypic Differences in Inflammatory Bowel Diseases Across Race, Ethnicity and Geography: A Systematic Review of 237 Population-Based Studies.

This global, transethnic meta-analysis revealed persistent differences in IBD phenotype and outcomes across ethnic groups. Future studies integrating multi-omic measurements in ethnically diverse populations are essential to elucidate the biologic basis of these variations.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain-DDR Study.

Between 2022 and 2024, double reflex diagnostic implementation expanded rapidly, demonstrating national feasibility and describing hepatitis D virus seroprevalence. However, regional inequities persist. Sustained uptake will require standardised reflex protocols, harmonization of viral load assays and continuous training to reduce underdiagnosis and improve care of coinfected patients.

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Real-World Performance of FIT Triage for Symptomatic Colonoscopy: Analysis of the UK National Endoscopy Database (NED).

This national analysis demonstrates the superiority of FIT-based triage over symptom-based referral, with FIT ≥ 10 identifying high-risk patients, including those aged 40-49, while FIT < 10 indicated very low risk.

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The Alpha-1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD.

The SERPINA1 Pi*MZ genotype is associated with an increased risk of HCC development in patients with ACLD, independently of other HCC risk factors.

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Am J Gastroenterol
Ethical and Practical Considerations for Mental Health Screening in Adult Patients with Inflammatory Bowel Disease.

The implementation of routine mental health screening for adults with IBD aligns with core ethical principles and supports comprehensive biopsychosocial care. With thoughtful implementation, gastroenterology practices can improve identification of depression and anxiety and facilitate timely access to appropriate mental health services.

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Low-dose aspirin continuation during gastric ESD in patients with low thrombotic risk: a randomized trial.

The non-inferiority of LDA continuation over discontinuation for ESD-related major bleeding in gastric ESD was not demonstrated. Therefore, discontinuation of LDA during the periprocedural period is recommended for patients with low thrombotic risk. (UMIN000013177).

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MELD-Lactate and lactate clearance in critically ill cirrhosis patients with sepsis.

Early reduction in initial LA by one-third predicts 30-day mortality and may indicate treatment response in cirrhosis patients with sepsis in the ICU. Combining MELD-LA and LA clearance early enables better risk stratification and informs management.

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Optimal Single or Combined Parameters for Dyssynergic Defecation on Anorectal Manometry: A Proof-of-Concept Machine Learning Study.

Two-hundred and twenty-two (72.3%) patients had a clinical diagnosis of DD. Compared to patients without clinical diagnosis of DD, patients with DD had significantly lower rectoanal pressure gradient (RAG) (median -34.7 [IQR -57.1, -13.0] vs -24.6 [IQR -44.5, -2.4] mmHg, p=0.009) and more abnormal BET (59.5% vs 11.8%, p 80% PPV for diagnosing DD in patients with chronic constipation.

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Clin Gastroenterol Hepatol
6-Mercaptopurine vs. Mycophenolate Mofetil in Autoimmune Hepatitis and Azathioprine Intolerance: A Multicenter Study.

Both 6-MP and MMF were capable of maintaining biochemical response in patients with AIH who were intolerant to AZA, with no clear evidence of inferiority of either treatment. While MMF was generally better tolerated, 6-MP may present a safe and effective treatment option in women of reproductive age. In addition, therapy with 6-MP enables clinicians to monitor drug metabolite levels, titrate dosages, and monitor adherence.

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Endosc Int Open
Characteristics and causes of post-endoscopy Barrett's neoplasia: Retrospective multicenter study.

PEBN occurring in LSBE was mostly overlooked because of inadequate observation, whereas PEBN at the 0 to 3 o'clock position in SSBE was frequently misdiagnosed as esophagitis. Bearing these results in mind may improve quality of endoscopic screening and reduce incidence of PEBN.

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Endoscopic submucosal dissection for early gastric cancer in the elderly: Spanish multicenter prospective study during initial experience.

Octogenarians with EGC benefit from ESD in a Western setting in terms of disease-free survival, but have lower long-term survival due to comorbidities, underscoring the importance of pre-procedure risk assessment. ESD is a proven safe technique, but in the subgroup of patients aged ≥ 80 years with severe comorbidities (ASA-PS ≥ IV), periprocedural mortality is increased and the indication should be carefully evaluated.

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Endoscopic ultrasound-guided radiofrequency ablation for large branch-duct intraductal papillary mucinous neoplasms: Safety and efficacy trial.

EUS-RFA in large, predominantly multilocular BD-IPMNs shows promising volumetric efficacy. Safety may be improved through refined energy delivery and technical advances. Molecular response remains exploratory and requires further validation. Long-term studies assessing progression-free outcomes are needed to define its role as an organ-preserving therapeutic option.

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Predictors of non-compliance with post-procedure follow-up after endoscopic stent placement.

Patient-specific risk factors for non-compliance of stent removal were identified. Patients with such risk factors may require extra education and communication efforts.

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Which patients with palliative malignant biliary obstruction will benefit most from biliary drainage: Development and validation of a prognostic score.

This score could be used in routine clinical practice to identify patients who have better survival outcomes after biliary drainage in palliative MBO.

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Endoscopy
Robot-Assisted Endoscopic Retrograde Cholangiopancreatography: A Pilot Study.

Despite the need for cautious interpretation in this limited cohort, our initial outcomes support the procedural feasibility of the robotic system and hint at its potential to assist in ERCP, but must be confirmed in larger studies.

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Gastrointest Endosc
Diagnostic value of magnifying endoscopy for colorectal laterally spreading tumor non-granular type.

Magnifying endoscopy has limited utility in therapeutic decision-making for LST-NG, particularly for PD lesions, indicating the importance of en bloc endoscopic resection whenever technically feasible, regardless of magnifying endoscopic findings.

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Endoscopic Ultrasound-Guided Coils Embolization with Cyanoacrylate Injection versus Transjugular Intrahepatic Portosystemic Shunt with Variceal Embolization for Gastric Variceal Bleeding: A Multicenter Propensity-Matched Analysis.

EUS-Coils+CYA and TIPS+VE showed comparable outcomes in controlling GV rebleeding and survival. Patients treated with EUS-Coils+CYA had a lower incidence of HE but carried a risk of ectopic embolism.

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Gut
NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis.

NSUN6 deficiency drives immune suppression through the m 5 C-KDM5A-CCL2 axis in PDAC. Targeting the NSUN6-CCL2 axis represents a promising strategy to sensitise PDAC to ICB therapy.

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Hepatology
Genomic and transcriptomic profiling of hepatocellular carcinoma in patients with Fontan-associated liver disease.

Genomic mutational profiles of FALD and non-Fontan CHS HCCs are distinct from HCCs with other etiologies. Copy number alterations and transcriptional profiles in FALD HCCs classified these into a poor-prognosis group of HCCs.

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Stroma-driven inter- and intratumoral heterogeneity of PD-L1 expression in cholangiocarcinoma: Implications for biomarker development and prognostic evaluation.

Our data indicate that stroma content may be a surrogate for inflamed iCCA. Moreover, the inter- and intratumoral heterogeneity of iCCA poses a significant challenge to interpreting the PD-L1 signal. To establish tissue-based biomarkers in iCCA, a more granular annotation of their expression in different intratumoral compartments will be critical.

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J Hepatol
A single-cell atlas of the woodchuck liver reveals cellular programs conserved in human HBV infection.

We present a multi-omic atlas of healthy, diseased, and ex vivo-stimulated woodchuck liver. This work identified shared WHV-HBV pathological processes, reinforces the value of this preclinical model and provides a resource to advance HBV pathogenesis studies and therapeutic development. Impact and implications Limited treatment options for liver disease, often requiring liver transplantation, emphasize the need for human-relevant animal models to speed the development of new therapeutic interventions. Woodchucks infected with woodchuck hepatitis virus (WHV) develop chronic hepatitis and liver cancer, similar to human hepatitis B virus (HBV) infection. However, the composition and active biological processes in woodchuck hepatic cells were poorly understood, limiting the utility of this model to therapeutic discovery. In this study, we characterized the healthy and chronically infected woodchuck liver in comparison to human HBV at a single-cell resolution reinforcing the potential of WHV-infected woodchuck as a model for human HBV disease.

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AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC: Effect of the BA/Butyrate/CXCL14 axis in HCC.

AF6 modulates primary BA synthesis, driving gut microbiota-dependent butyrate production and Cxcl14-mediated immune remodeling in HCC. This axis highlights a novel mechanism linking BA metabolism, gut microbiota, and immune regulation, offering potential therapeutic targets for liver cancer treatment. Impact and implications This study establishes that hepatic Af6 deficiency restrains hepatocarcinogenesis via a BA-driven, microbiota-dependent butyrate-CXCL14 axis. This axis highlights a novel mechanism linking BA metabolism, gut microbiota, and immune regulation, providing potential therapeutic targets for liver cancer treatment. This research represents the first mouse model in which induces the generation of primary BAs is potentiated without associated alterations in the typical epithelial morphology. We expect that this model will be of use in monitoring BA-related pathological processes in the gastrointestinal tract, including cancer progression.

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Incidence and implications of abstinence-induced recompensation in alcohol-related cirrhosis.

Alcohol abstinence enabled recompensation in one third of patients with decompensated alcohol-related cirrhosis, particularly with early abstinence and absence of further decompensation. Recompensation led to a significant survival benefit with maintained abstinence, with a negligible residual risk of liver-related death and HCC. Impact and implications Hepatic recompensation, as defined by Baveno VII, is a novel clinical concept reflecting the potential for disease regression and resolution of decompensating events in patients with cirrhosis once the underlying aetiological factor is removed or controlled. In this multicentre study, sustained alcohol abstinence led to recompensation in one third of patients with decompensated alcohol-related cirrhosis within 5 years, particularly if abstinence was achieved early and in the absence of further decompensation. Recompensation markedly improved outcomes, with a negligible residual risk of liver-related death and hepatocellular carcinoma when abstinence is maintained. These findings support personalised treatment approaches in decompensated alcohol-related cirrhosis by helping identify patients at risk of progression or with potential for regression.

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Updated data from IMbrave050: Adjuvant atezolizumab plus bevacizumab for high-risk hepatocellular carcinoma.

In this updated analysis, the initial RFS benefit seen with atezolizumab plus bevacizumab vs active surveillance was not sustained and OS remained immature. The safety profile of atezolizumab plus bevacizumab remained manageable and consistent with that of each agent and the underlying disease. Overall, the benefit-risk profile does not support atezolizumab plus bevacizumab as adjuvant therapy. Clinical trial number NCT04102098 IMPACT AND IMPLICATIONS Based on results from the IMbrave150 trial, atezolizumab in combination with bevacizumab is the standard-of-care first-line treatment for unresectable HCC, prompting interest in investigating the combination in earlier treatment settings. IMbrave050 was the first immunotherapy study to report data in the adjuvant setting for HCC, where an early RFS benefit was observed at the pre-specified interim analysis but not maintained with longer follow-up; overall survival remained immature. The updated results of IMbrave050 do not support the use of atezolizumab plus bevacizumab in the adjuvant setting. However, subgroup analyses suggest a potential benefit in select patients, warranting further prospective evaluation. Effective perioperative or adjuvant treatment remains a major unmet need for patients with HCC given the high rate of early post-operative relapse.

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Yttrium-90 radioembolization is associated with a lower risk of liver transplant waitlist dropout than chemoembolization in hepatocellular carcinoma.

In a large national cohort of liver transplant candidates with HCC, TARE compared to TACE as first LRT was associated with higher rates of complete necrosis on explant, lower likelihood of multiple LRTs, and lower risk of waitlist dropout. Impact and implications With nearly al hepatocellular carcinoma (HCC) patients in the US now receiving local regional therapies (LRT), better understanding of the optimal LRT type to achieve tumor control and maintain tumor stage is needed. In this contemporary study of over 5000 patients using the US national database (UNOS), we showed that trans-arterial radioembolization (TARE) may be the preferred bridging therapy over chemoembolization (TACE) based on a significantly lower probability of waitlist dropout after controlling for liver function and tumor characteristics. Additionally, TARE treated patients demonstrated higher probability of complete pathologic response and reduced tumor under-staging on explant, which taken together strongly suggests that TARE is a more effective tumor treatment compared to TACE.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol
Blue Notes.

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Knowledge, Attitudes, and Environment Related to Gastroenterology and Hepatology Care for Sexual and Gender Minorities.

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Gut
Shaping the future of postoperative recurrence in Crohn's disease: personalised approaches with AI-enabled imaging and multi-omics.

While promising, these innovations require prospective validation, methodological standardisation and integration into clinical workflows before translation into routine practice. This review summarises the current understanding of POR, highlights emerging diagnostic and monitoring technologies and explores how AI-enabled endoscopy and multi-omics approaches may transform future management, paving the way towards precision medicine for POR in CD.

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J Hepatol
Revisiting Prophylactic Corticosteroids to Mitigate Severe Immune-Related Adverse Events in Hepatocellular Carcinoma.

Judicious PC use may offer a practical means to mitigate severe irAEs-particularly in anti-CTLA-4-containing regimens-while maintaining antitumor activity. We advocate for prospective evaluation of PC in ICI-based combinations with higher immune-mediated toxicity to better define their role in HCC.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Clin Gastroenterol Hepatol
Seladelpar improves cholestasis and pruritus in obeticholic acid and fibrate-experienced patients with PBC.

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Endosc Int Open
Endoclip and snare combined traction and resection for treating gastric submucosal tumor with extraluminal growth.

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Novel endoscopic resection of synchronous dual gastric lesions using a compact robotic arm system.

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Endoscopy
A novel application of the submucosal tunnel technique for resection of a giant duodenal lipoma.

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Beyond the weekend: great potential for photometric capsule-based risk assessment.

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Bridge formation method for endoscopic submucosal dissection of early gastric neoplasms along the lesser curvature at the gastric angle.

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Clinical and methodological considerations in artificial intelligence-assisted endoscopic ultrasonography for pancreatic mass detection.

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Comments on "Comparing low volume versus intermediate volume bowel preparation and their impact on work and tolerability".

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Endoscopic laser lithotripsy for a pancreaticojejunostomy stricture using a novel ultra-slim cholangiopancreatoscope via an endoscopic ultrasound-guided pancreatogastrostomy route.

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Endoscopy E-Videos - recently published.

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Gastric inverted polyp mimicking submucosal tumor.

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Novel needle system for transmural access in therapeutic endoscopic ultrasound.

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Novel use of cholangioscopy-assisted enteroscopy for foreign body removal from a narrow-ostium ileal diverticulum.

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Removal of an over-the-scope clip using balloon dilation.

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Rescue endoscopic ultrasound-guided hepaticogastrostomy with antegrade stenting for food-impacted complete papillary occlusion via intentional stent-mesh traversal.

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Simultaneous bridging and antegrade stent-in-stent placement via endoscopic ultrasound-guided hepaticogastrostomy using novel multi-hole metal stents.

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Single-operator esophageal endoscopic submucosal dissection using an endoscope-tethered adjustable knife.

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Successful endoscopic management of post-coloplasty cervical esophagocutaneous fistula using sequential diabolo and fully covered stents.

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Gastroenterology
Core Experiences in Gastropsychology Fellowship Training.

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Knowledge, Attitudes, and Environment Related to Gastroenterology and Hepatology Care for Sexual and Gender Minorities.

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Gastrointest Endosc
Endoscopic fistulotomy for managing refractory gastrocutaneous fistulas following laparoscopic sleeve gastrectomy: an effective and simple method.

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Intraductal Papillary Mucinous Neoplasm Arising in Gastric Ectopic Pancreas.

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Making the Inaccessible Biopsiable: Overtube-Assisted EUS Post-Whipple.

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Non-Confluent Hepatic Ducts Draining Separately into the Duodenum: A Unique Biliary Tree Variant.

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Underwater Resection of Redundant Jejunal Folds Causing Recurrent Cholangitis After Whipple Procedure.

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Uvular Necrosis After Routine Diagnostic Endoscopy: A Rare Adverse Event.

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Gut
Kupffer cell autophagy emerges as a central regulator of immune dysregulation in primary biliary cholangitis.

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Role of TL1A in perianal fistulising Crohn's disease: a new therapeutic target?

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Hepatology
Letter to the Editor: From weight to waist: Refining fibrosis prediction in the global MASLD cohort.

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Letter to the editor: Deep learning and digital pathology for HCC prediction in steatotic liver disease.

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Reply: From weight to waist: Refining fibrosis prediction in the global MASLD cohort.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Letter: Trajectories of Hepatic Function Markers Enable Early Prediction of Hepatic Recompensation-Authors' Reply.

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Letter: Trajectories of Hepatic Function Markers Enable Early Prediction of Hepatic Recompensation.

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Clin Gastroenterol Hepatol
Non-paired comparison of EUS-guided and transjugular liver approaches using different needles: can firm conclusions be made?

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Gastroenterology
Dietary Flexibility as a Pathway to Nutritional Remission in Crohn's Disease.

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Reconsidering the Microbiome and Maintenance Claims in Whole-Food Dietary Trials for Crohn's Disease.

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J Hepatol
Absolute risk estimation of liver disease cannot be based on time-varying covariates.

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